Scientists identified a potential connection between genetic mutations and epigenetic watches, shedding a new light on the mechanisms behind biological aging. This discovery can reshape as aging is understood and measured. The study explores how DNA Mutations that accumulate over time can directly influence epigenetic changes, which are often used to estimate biological age. The researchers examined these connections in detail, in order to determine whether these processes drive aging or just reflect. The results suggest that there is a deeper relationship between these genetic changes, which may have significant implications for longevity research.
Genetic and epigenetic changes in aging
According to a to study Published in the nature of aging on January 13, a correlation between random genetic mutations and epigenetic modifications that contribute to biological aging was observed. DNA mutations, which arise from cell replication errors, environmental factors and the gradual decline of repair mechanisms, have long been associated with age -related diseases such as cancer and neurodegeneration. However, these mutations alone do not completely explain aging.
Epigenetic changes, which regulate gene activity without changing the DNA sequence, were widely studied using “epigenetic watches.” These clocks track specific DNA markers to estimate biological age. The study suggests that mutations influence these markers and, in turn, epigenetic modifications may affect mutation patterns. This bidirectional relationship has raised new questions about whether epigenetic changes are only symptoms of aging or active participants in the process.
Scientific perspectives on discoveries
Dr. Steven Cummings, Executive Director of the San Francisco Coordination Center of the University of California, San Francisco, declared To live science, a strong correlation was identified between DNA mutations and epigenetic markers. According to him, the study indicates that mutations in specific places of DNA result in distinct epigenetic changes, leading to waterfall effects throughout the genome.
Professor Trey Ideker of the University of California, San Diego, added that a significant loss of DNA methylation was observed in mutated places, while surrounding areas exhibited greater methylation. This waterfall effect extended thousands of pairs of bases beyond the original mutation, although the precise mechanism remains uncertain. He emphasized the need for further research to determine whether mutations trigger epigenetic changes or vice versa.
Implications for the aging of research
Study findings suggest that genetic and epigenetic changes may be influenced by an underlying process that remains unidentified. Dr. Cummings proposed that DNA mutations could be the main factors of aging, while epigenetic changes may reflect this process rather than cause it. If confirmed, this would have a significant challenge for anti -aging research, as reversal mutations are considerably more complex than modification of epigenetic markers.
Experts have pointed out that additional studies are needed to validate these conclusions, especially in non -carcinogenic tissues. The data used in the study were mainly derived from cancer patients, making it necessary to examine whether the same standards exist in healthy individuals. Longitudinal studies tracking genetic and epigenetic changes over time can provide a clearer image of their relationship with aging.
Advance investigations It may include laboratory experiments where specific mutations are induced in cells to observe subsequent epigenetic modifications. These ideas can help refine the use of epigenetic clocks and lead to a broader understanding of molecular aging.