First rat with two parents thrives in adulthood, marking new scientific milestones

A great development in Cell -Turn Science has been achieved with the creation of a bil-paternal mouse, marking a significant step in reproductive biology. Scientists successfully designed a rat with two male biological parents who managed to survive in adulthood. This survey, conducted by a team of stew cell specialists, addressed longtime barriers in unisexual mammalian reproduction, modifying specific print genes. Discoveries, which may have implications for Regenerative medicineHighlight the challenges and possible future applications of technology.

Genetic modifications allow billet development

According to the to study Posted in Cells -Tonco Mobile Mobiles, led by Wei Li do Chinese Academy of Sciences (Cas), the team focused on overcoming challenges related to immensely that previously prevented embryos with Same genetic origins of development totally. Modifications have been made to 20 print genes using techniques such as changing frames, gene deletions and editions of the regulatory region. These changes allowed some bi-paternal embryos to survive at birth and, in rare cases, to reach adulthood.

Co-corresponding author Qi Zhou de Cas explained For Phys.org, which print genes were identified as a fundamental obstacle in unisexual reproduction. Despite previous attempts using ovarian organoids derived from male cells, the impression of abnormalities caused serious defects of development. By directly editing these genes, the research team improved embryonic viability and stability of the multipotent stem.

Survival and reproductive challenges remain

According to reports, only 11.8 % of projected embryos developed for birth, and those who survived exhibited abnormalities in development, reduced service life and sterility. Guan-Zheng Luo of Sun Yat-Sen University, a co-corresponding author, said the abnormalities of printing were confirmed as the main factor that prevents unisexual reproduction in mammals.

Despite limitations, this approach has shown the potential to refine stem cell-based therapies and improve cloning efficiency. Researchers plan to expand study to larger mammals, although substantial challenges remain due to differences in the printing of genetic patterns between species.